Sitagliptin +
Metformin Tablets

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Therapeutic Indication

Type 2 Diabetes Mellitus
Improves glycemic control
Used when monotherapy is insufficient
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Sitagliptin and Metformin Tablets

Tablet

Sitagliptin IP 50 mg /500 mg & Metformin Hydrochloride Tablet is a dipeptidyl peptidase-4 (DPP-4) inhibitor and biguanide combination product indicated as an adjunct to diet and exercise to improve glycemic control in adults with type 2 diabetes mellitus. They help your pancreas produce more insulin, facilitate the effective use of insulin by the body, and reduce excess sugar that your liver makes. Together, they provide better control of blood sugar.

Speciality Anti-Diabetic | Endocrinology
Tags DPP-4 Inhibitor | Oral Hypoglycemic
Strength
  • Sitagliptin 50 mg
  • Metformin Hydrochloride 500 mg/1000 mg
Packing Size
  • 15 Tablets

Check all Tablets Range

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Mechanism

Sitagliptin works by increasing levels of natural substances called incretins. Incretins help to control blood sugar by increasing insulin release, especially after a meal. They also decrease the amount of sugar your liver makes. Metformin works by helping to restore your body's proper response to the insulin you naturally produce. It also decreases the amount of sugar that your liver makes and that your stomach/intestines absorb.

Side Effects

  • Headache
  • Upper respiratory infection
  • Upset stomach

Contraindication

  • Sitagliptin and Metformin is contraindicated in patients with previous hypersensitivity to Sitagliptin and Metformin or any other component of this drug
  • If any have kidney problems, heart diseases
  • Type 1 disease
  • Metabolic acidosis, including diabetic ketoacidosis

Interaction

  • Cationic drugs (ranitidine, amiloride, digoxin) → compete with metformin renal clearance.
  • Alcohol → ↑ risk of lactic acidosis.
  • Sulfonylureas/insulin → ↑ hypoglycemia risk.
  • Sulfonylureas/insulin → ↑ hypoglycemia risk.
  • Strong CYP3A4 inhibitors (ketoconazole, ritonavir) → ↑ sitagliptin exposure

Warning and Precautions

  • Renal Function Monitoring, Lactic Acidosis risk
  • Metformin may rarely cause lactic acidosis, Pancreatitis
  • Caution: Sitagl iptin has been associated with cases of acute pancreatitis

Dosage

As directed by the Physician.

Disclaimer

All product details on this website are for reference and informational purposes only and are not directed at patients or consumers.
As a contract manufacturer, DM Pharma Pvt Ltd is not responsible for the marketing or end use of these products and disclaims all liability arising from reliance on this information.
Please consult a healthcare professional before using any medicinal product.